ABSTRACT
Human intestinal capillariasis is caused by Capillaria philippinensis. This disease is endemic in Philippines and Thailand. To the best of our knowledge, we report the third case of human intestinal capillariasis from India and the first case from Andhra Pradesh, which is a non-endemic area. A 40-year-old female presented with diarrhoea, vomiting, decreased urinary output, ascitis, pedal oedema, hypoalbuminemia, and electrolyte imbalance. Microscopic examination of stool sample revealed the presence of ova, larvae, and adult worms of C. philippinensis. Patient recovered from the disease after taking albendazole 400 mg daily for 1 month along with supportive treatment.
Subject(s)
Adult , Albendazole/administration & dosage , Animals , Anthelmintics/administration & dosage , Capillaria/isolation & purification , Enoplida Infections/diagnosis , Enoplida Infections/drug therapy , Enoplida Infections/parasitology , Enoplida Infections/pathology , Feces/parasitology , Female , Helminthiasis/diagnosis , Helminthiasis/drug therapy , Helminthiasis/parasitology , Helminthiasis/pathology , Humans , India , Intestinal Diseases/diagnosis , Intestinal Diseases/drug therapy , Intestinal Diseases/parasitology , Intestinal Diseases/pathology , Microscopy , Treatment OutcomeABSTRACT
We encountered an indigenous case of intestinal capillariasis with protein-losing enteropathy in the Republic of Korea. A 37-year-old man, residing in Sacheon-si, Gyeongsangnam-do, admitted to the Gyeongsang National University Hospital (GNUH) due to long-lasting diarrhea, abdominal pain, anasarca, and weight loss. He recalled that he frequently ate raw fish, especially the common blackish goby (Acanthogobius flavimanus) and has never been abroad. Under the suspicion of protein-losing enteropathy, he received various kinds of medical examinations, and was diagnosed as intestinal capillariasis based on characteristic sectional findings of nematode worms in the biopsied small intestine. Adults, juvenile worms, and eggs were also detected in the diarrheic stools collected before and after medication. The clinical symptoms became much better after treatment with albendazole 400 mg daily for 3 days, and all findings were in normal range in laboratory examinations performed after 1 month. The present study is the 6th Korean case of intestinal capillariasis and the 3rd indigenous one in the Republic of Korea.
Subject(s)
Adult , Animals , Female , Humans , Male , Albendazole/administration & dosage , Anthelmintics/administration & dosage , Biopsy , Capillaria/cytology , Diarrhea , Enoplida Infections/drug therapy , Feces/parasitology , Helminthiasis/drug therapy , Intestinal Diseases, Parasitic/drug therapy , Intestines/parasitology , Protein-Losing Enteropathies/drug therapy , Republic of Korea , Treatment OutcomeABSTRACT
Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.
Subject(s)
Animals , Male , Female , Rats , Antibodies, Helminth/blood , Antigens, Helminth/administration & dosage , Capillaria/immunology , Enoplida Infections/parasitology , Liver Cirrhosis, Experimental/parasitology , Chronic Disease , Disease Models, Animal , Enoplida Infections/drug therapy , Enoplida Infections/immunology , Glucocorticoids/therapeutic use , Hydroxyproline/analysis , Liver Cirrhosis, Experimental/drug therapy , Liver Cirrhosis, Experimental/immunology , Prednisone/therapeutic use , Rats, Wistar , Severity of Illness IndexABSTRACT
Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected